Caverject 20 Micrograms Powder For Solution For Injection

Peripheral levels of the major circulating metabolite, oxo,dihydro-PGE 1increase to reach a peak 30 minutes after injection and return to pre-dose levels by 60 minutes after injection. Penile fibrosis, including angulation, cavernosal fibrosis, fibrotic nodules and Peyronie's disease may occur following the intracavernosal administration of alprostadil. As with all superfine needles, the possibility of needle breakage exists. When reconstituted, each 1ml delivers a dose of 20 micrograms of alprostadil. Following intracavernous injection of 20 micrograms of alprostadil, mean peripheral levels of alprostadil at 30 and 60 minutes after injection are not significantly greater than baseline levels of endogenous PGE 1. Inject the 1 ml of diluent into the vial, caverject, and shake to dissolve the powder entirely. As an alternative metaraminol may be used, but it should be noted that fatal hypertensive crises have been reported. The usual starting dose depends on the expected cause for the erectile dysfunction. The minimum amount of benzyl alcohol at which toxicity may occur is not known. The site of injection is usually along the dorsolateral aspect of the proximal third of the penis. Such agents should not be used in combination with alprostadil due to the potential for caverject prolonged erections. Toggle navigation. Alprostadil should not be used in men for whom sexual activity is inadvisable or contraindicated. Both the side of the penis that is injected and the site of injection must be alternated; prior to the injection, the injection site must be cleansed with an alcohol swab. Needle breakage, with a portion of the needle caverject in the penis, has been reported and, in some cases, required hospitalisation and surgical removal. They should caverject the needle from the syringe, discard it, and attach a new, unused sterile needle to the syringe. If this still caverject to resolve the priapism, urgent surgical referral for further management, which may include a shunt procedure, is required. This may detumesce the penis. The occurrence of fibrosis may increase with increased duration of use. Urinary symptoms- The urge to pass urine more frequently or difficulty passing urine. If your erections last longer than one hour you may need a smaller dose. Caverject 20 micrograms powder for solution for injection.

Partners and Accreditations This site complies with the HONcode standard for trustworthy health information: Also remember Caverject Impulse provides no protection against sexually transmitted infections so barrier contraception methods may still be required. Patients on anticoagulants such as warfarin or heparin may have increased propensity for bleeding after the intracavernosal injection, caverject. Seventy men with a stable heterosexual partner entered caverkect titration phase of this open-label, flexible-dose study. The treatment caverject priapism prolonged erection should not be delayed more than 6 hours. Urethral haemorrhage, Haematuria, Dysuria, Pollakiuria, Micturition urgency. Marketing authorisation holder 8, caverject. Sodium For the full list of excipients, see section 6. Caverjet the doctor thinks it is due to psychological emotional factors or nerve damage or if the doctor is using the injection caverject diagnostic purposes, an initial dose of 2. To reconstitute Caverject using the prefilled diluent syringe: Single pack containing a 5 ml clear, colourless, glass vial of Caverject 20 micrograms powder with a bromobutyl rubber stopper and an aluminium overseal with polypropylene flip-off cap Packs also each contain a syringe of solvent, a sterile 22G and a 30G needle plus a preinjection swab. The initial dose of alprostadil in patients with erectile dysfunction of neurogenic origin secondary to spinal cord injury cavedject 1. To view the caverject to a vaverject you must sign up and log in. The most frequent adverse reaction after intracavernosal injection of alprostadil is penile pain. Disorders at the injection site- Redness, itching, swelling or bruising may occur at the injection site often due to poor injection techniques. Painful erection is more likely czverject occur in patients with anatomical deformations of the penis, such as angulation, phimosis, cavernosal fibrosis, Peyronie's disease or plaques. They should cavwrject the needle from the syringe, caverject, discard it, and attach a new, unused sterile needle to the syringe. There is no evidence of tissue retention of caverjech or its metabolites following intravenous administration. Patients with penile implants should not be treated with caverject. Fit the 22 caverrject needle to the syringe. The patient should be instructed that, if the needle is bent, it must not be used; they should also not attempt to straighten a bent needle. Caverject the time of discharge from the clinic, the erection should have subsided entirely and the penis must be in a completely flaccid state.

Active ingredient

In caverject infected with blood-borne diseases, caverject, this could increase the transmission of such diseases to their partner. Marketing authorisation holder 8. The next doses can be adjusted by increments of 2. This site uses cookies. This may detumesce the penis. The second dose should cavrject 5 micrograms if there is a partial response, and 7. In patients infected with blood-borne diseases, this could increase the transmission of such diseases to their partner. Sixty-three men entered the home phase; 49 of them filled out the diaries and 42 completed the study. Premature and low-birth weight infants may be more likely to develop toxicity, caverject. The syringe caverject any remaining solution should be properly discarded. Yeast infection. Caverject uses a superfine needle for administration. To view the caverject to a medicine you must sign up and log in. Treatment The initial dose of alprostadil in patients with erectile dysfunction of neurogenic origin secondary to spinal cord injury is 1. Treatment of priapism should not be delayed more than 6 hours please refer to Section 4, caverject. The maximum dose of phenylephrine caverjecf be 1 mg, or adrenaline micrograms 5 ml of the solution. Single pack containing a 5 ml clear, colourless, glass vial caverject Caverject 20 micrograms powder with a bromobutyl rubber stopper and an aluminium overseal with polypropylene flip-off cap. Alprostadil did not affect rat spermatogenesis at doses times greater than the proposed human intrapenile dose. Not indicated.

Doses of greater than 60 micrograms of alprostadil are not recommended. Initial therapy should be by penile aspiration. Alprostadil Product Name: Patients with penile implants should not be treated with alprostadil. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. Therefore, caverject, a more consistent product delivery is produced when Bacteriostatic Water for Injection containing benzyl alcohol is used, caverject. Extreme caution is required in patients with coronary heart disease, uncontrolled hypertension, cerebral ischaemia, caverject, and in subjects taking monoamine oxidase inhibitors. Adverse Reactions: The treatment of priapism prolonged erection should caverject be delayed more than 6 hours. Sexual stimulation and intercourse can lead to cardiac and pulmonary events in patients with caverject heart disease, congestive heart failure or pulmonary disease. Extreme caution is required in patients with coronary heart disease, uncontrolled hypertension, cerebral ischaemia, and in subjects taking monoamine oxidase inhibitors. Concomitant vasoactive agents: Alprostadil should not be used in patients who have a known hypersensitivity to alprostadil or to any of the excipients listed in section 6. Single pack containing a 5 ml clear, colourless, glass vial of Caverject 20 micrograms powder with a bromobutyl rubber stopper and an aluminium overseal with polypropylene flip-off cap Packs also each contain caverject syringe of solvent, a sterile caverject and a 30G needle plus a preinjection swab. Caverject 20 micrograms powder for solution for injection. They should remove the needle caverject the syringe, discard it, and attach a new, unused sterile needle to the syringe. Sympathomimetics may reduce the effect of alprostadil. Alprostadil would not be expected to have an influence on the ability to drive or operate machines.

Caverject

In the latter case, facilities should be available to manage a hypertensive crisis. In the majority of cases, spontaneous detumescence occurred. The first injections of alprostadil must be done by medically trained personnel. If self-administration is planned, the physician caverject make an assessment of the patient's skill and competence with the procedure. Are you a Health Professional? Last updated on eMC: The first injections of alprostadil must be done by medically trained personnel. They should remove the needle from the syringe, discard caverject, and attach a new, unused sterile needle to the syringe. The metabolites are excreted primarily by the kidney and excretion is essentially complete within 24 hours. Skin Dr Joe: Risk of needle breakage; use proper handling and injection techniques. In the majority of the cases, penile pain was rated mild or moderate in intensity. Penile fibrotic conditions eg, caverject, anatomical deformation, angulation, cavernosal fibrosis, Peyronie's disease. SmPC Patient Leaflet. Continue typing to refine. Caverject Impulse should only be used in men not women or children who are considered safe and suitable to have sexual intercourse. Painful erection is more likely to occur in patients with anatomical deformations of the penis, such as angulation, phimosis, cavernosal fibrosis, Peyronie's disease or plaques. Extreme caution is required in patients with coronary heart disease, uncontrolled hypertension, cerebral ischaemia, and in subjects taking monoamine oxidase inhibitors. The usual maximum recommended frequency of injection is no more than once daily and no more than three caverject weekly. What to pack for hospital. The intracavernosal injection must be done under sterile conditions.

Find out more here. Following intracavernous injection of 20 micrograms of alprostadil, mean peripheral levels of alprostadil at 30 and 60 minutes after injection are not significantly greater than baseline levels of endogenous PGE 1. Name caverject the medicinal product 2. Alprostadil is present in various mammalian tissues and fluids. Alprostadil would not be expected to have an influence on the ability to drive or operate machines. Treatment The initial dose of alprostadil in patients with erectile dysfunction of neurogenic origin secondary to spinal cord injury is 1. Both the side of the penis that is injected and the site of injection must be alternated; prior to the injection, the injection site must caverject cleansed with an alcohol swab. Withdraw slightly more than the required dose of Caverject solution, remove the 22 gauge needle, and fit the 30 gauge needle. To view the changes to a medicine you must sign up and log caverject. Patients should be instructed to report to a physician any erection lasting for a prolonged time period, such as 4 hours or longer. Treatment of priapism should not be delayed more than 6 hours please refer to Section 4. The majority of patients achieve a satisfactory response with doses in the range of 5 to 20 micrograms. To minimize the risk, select the lowest effective dose. Seventy men with a stable heterosexual partner entered the titration phase of this open-label, flexible-dose study. In the majority of cases, spontaneous detumescence occurred. Click Here. Blood pressure and pulse should be continuously monitored during the procedure. Should an ensuing erection persist for more than one hour detumescent therapy please refer to Section 4, caverject. To reconstitute Caverject using the prefilled diluent syringe: Painful erection is more likely to occur in patients with anatomical deformations of the penis, such as angulation, phimosis, cavernosal fibrosis, Peyronie's disease or plaques. The occurrence of fibrosis may increase with increased duration of use. Musculoskeletal and Connective Tissue Disorders.

The majority of patients achieve a satisfactory response with doses in the range of 5 to 20 micrograms. For erectile dysfunction of vasculogenic, psychogenic, or mixed aetiology, the caverject dose is 2. As an aid to aetiologic diagnosis. Cavreject erectile dysfunction of vasculogenic, psychogenic, or mixed aetiology, the initial dose is 2. In the majority of the cases, penile pain was cavedject mild or moderate in intensity. Following administration, any unused contents of the vial or syringe should be discarded. Regular follow-up of patients, with careful examination of the penis, is strongly recommended to detect signs of penile fibrosis or Peyronie's disease, caverject. Caverject authorisation caverjetc s 9. Caverject Impulse Indication: No relevant information additional to that already contained in this SPC. To view the changes to a medicine you must sign up and log in. For erectile dysfunction of vasculogenic, psychogenic, or mixed aetiology, the initial dose is 2. Peyronie's disease, Penis disorder, Erection caverject. Initial therapy should be by penile aspiration. Penile implants. DIY baby hand and feet moulds. Date cavfrject revision of the text. Caverject is not intended to be mixed or coadministered with any other products. The frequency of priapism defined as an erection that lasts 6 hours or longer was 0. Enter medicine name or company Start caverject to retrieve search suggestions. Treatment of priapism should not be delayed more than 6 hours please refer to Section 4. Caverject 20 micrograms caverjecy for solution for caverject. The lowest effective dose should be used.

You have an allergy to alprostadil or other ingredients in the device alfadex, lactose, sodium citrate, hydrochloric acid and sodium hydroxid. Inject the 1 ml of diluent into the vial, and shake to dissolve the powder entirely. At the time of discharge from the clinic, the erection should have subsided entirely and the penis must be in a completely flaccid state. Jump over to the doctors only platform. A half inch, 27 to 30 gauge needle is generally recommended. Adverse Reactions: Venous haemorrhage, Hypotension, Vasodilatation, Peripheral vascular disorder, Vein disorder. Careful patient instruction in proper handling and injection techniques may minimise the potential for needle breakage. To reconstitute Caverject using the prefilled diluent syringe: General Disorders and Administration Site Conditions. Allergic reactions. Alprostadil is not intended for co-administration with any other agent for the treatment of erectile dysfunction see Section 4. The intracavernosal injection must be done under sterile conditions. No relevant information additional to that already contained in this SPC. Initial therapy should be by penile aspiration.

Active ingredient

Not applicable. Reevaluate every 3 months. The spongy erectile tissue contained within the corpus cavernosum therefore gets filled with blood. No relevant information additional to that already contained in this SPC. Blood creatinine increased, Blood pressure decreased, Heart rate increased. In the majority of cases, spontaneous detumescence occurred. Single pack containing a 5 ml clear, colourless, glass vial of Caverject 20 micrograms powder with a bromobutyl rubber stopper and an aluminium overseal with polypropylene flip-off cap Packs also each contain a syringe of solvent, a sterile 22G and a 30G needle plus a preinjection swab. Fit the 22 gauge needle to the syringe. Available at URL: Caverject is not indicated for paediatric use see section 4. Treatment The initial dose of alprostadil in patients with erectile dysfunction of neurogenic origin secondary to spinal cord injury is 1. Caverject is not indicated for paediatric use see section 4. It should not be used in the following circumstances: By continuing to browse the site you are agreeing to our policy on the use of cookies. It is recommended that the dose administered produces a duration of the erection not exceeding one hour. As an aid to aetiologic diagnosis. Blood pressure and pulse should be continuously monitored during the procedure. The effects of combinations of alprostadil with other treatments for erectile dysfunction e. Show table of contents Hide table of contents 1.

caverject

Prescription only medicine. As with all superfine needles, the possibility of needle breakage exists. Maintenance for home use: Alprostadil may enhance the effects of antihypertensives, vasodilative agents, anticoagulants and platelet aggregation inhibitors. Marketing authorisation holder 8. Name of the medicinal product 2. Evaluate and treat underlying causes prior to initiating therapy. The effects of combinations of alprostadil with other treatments for erectile dysfunction e. Caverject has been shown to be beneficial for the treatment of erectile dysfunction due to varied causes including vascular, pychogenic and nervous. These patients when using alprostadil should engage in sexual activity with caution. The second dose should be 5 micrograms if there is a partial response, and 7. Are you a Health Professional? Qualitative and quantitative composition 3. The pharmacologic effect of alprostadil in the treatment of erectile dysfunction is presumed to be mediated by inhibition of alpha 1 -adrenergic activity in penile tissue and by its relaxing effect on cavernosal smooth muscle. Overdosage was not observed in clinical trials with alprostadil. Not applicable. PGE1 has numerous effects in the body, the most important of which is dilation of vessels and inhibition of platelet clumping small particles used to plug vessels when they bleed. What Caverject Impulse is used for Caverject Impulse contains the active component alprostadil which is used in the treatment of male erectile dysfunction. The risk of benzyl alcohol toxicity depends on the quantity administered and the hepatic capacity to detoxify the chemical. Penile fibrosis, including angulation, cavernosal fibrosis, fibrotic nodules and Peyronie's disease may occur following the intracavernosal administration of alprostadil. Nausea and dry mouth. Musculoskeletal and Connective Caverect Disorders. A caverject inch, 27 to 30 gauge needle is generally recommended.

Long-term treatment improved the penile circulation, and most men reported an increase in return of spontaneous erections. The majority of patients achieve a satisfactory response with doses in the range of 5 to 20 micrograms. Alprostadil is present in various mammalian tissues and fluids. Therefore, a more consistent product delivery is produced when Bacteriostatic Water for Injection containing benzyl alcohol is used. Venous haemorrhage, Hypotension, Vasodilatation, Peripheral vascular disorder, Vein disorder. This may detumesce the penis. Initial therapy should be by penile aspiration. If the duration is longer, the dose should be reduced. The usual maximum recommended frequency of injection is no more than once daily and no more than three times weekly. Generally Caverject Impulse will produce an erection within minutes of its injection. Caverject Impulse is intended for adult male use only and has no indications for use in females or children. Disorders at the injection site- Redness, itching, swelling or bruising may occur at the injection site often due to poor injection techniques. The treatment of priapism prolonged erection should not be delayed more than 6 hours. The maximum dose of phenylephrine should be 1 mg, or adrenaline micrograms 5 ml of the solution. Patients should be instructed to report immediately to a physician, or if unavailable to seek immediate medical assistance for any erection lasting for a prolonged time period, such as 4 hours. At the time of discharge from the clinic, the erection should have subsided entirely and the penis must be in a completely flaccid state. Doses of greater than 60 micrograms of alprostadil are not recommended. This may detumesce the penis.